Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa.

Author information

Institute of Psychiatry – Federal University of Rio de Janeiro. Laboratory of Panic and Respiration. Rua Visconde de Piraja, 407/702, Rio de Janeiro, RJ. CEP 22410-003, Brazil.


Anxiety and depression are pathologies that affect human beings in many aspects of life, including social life, productivity and health. Cannabidiol (CBD) is a constituent non-psychotomimetic of Cannabis sativa with great psychiatric potential, including uses as an antidepressant-like and anxiolytic-like compound. The aim of this study is to review studies of animal models using CBD as an anxiolytic-like and antidepressant-like compound. Studies involving animal models, performing a variety of experiments on the above-mentioned disorders, such as the forced swimming test (FST), elevated plus maze (EPM) and Vogel conflict test (VCT), suggest that CBD exhibited an anti-anxiety and antidepressant effects in animal models discussed. Experiments with CBD demonstrated non-activation of neuroreceptors CB1 and CB2. Most of the studies demonstrated a good interaction between CBD and the 5-HT1A neuro-receptor.


Other Therapeutic Uses and Remedies

General ResearchAcneADD – ADHD
Alzheimer’sAnorexiaAntibiotic Resistance
AsthmaAutismBipolar Disorder
CancerChronic PainDigestive Issues
DepressionDiabetesEndrocine Disorders
Epilepsy and SeizuresFibromyalgiaGlaucoma
Heart DiseaseHuntington’s DiseaseInflammation
Irritable Bowel SyndromeLiver DiseaseMetabolic Syndrome
MigraineMood DisordersMotion Sickness
Multiple Sclerosis – MSNauseaNeurodegeneration
Parkinson’s DiseasePTSDRheumatism
SchizophreniaSickle Cell AnemiaSkin Conditions
Sleep DisordersStressStroke

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