Terpene - Terpinolene

Terpene – Terpinolene


EFFECTS: Anti-bacterial, Anti-cancer, Antioxidant, Sedative.
Strains containing Terpinolene include: Durban Poison.

Terpinolene is a common terpene primarily isolated from trees. It is present in high amounts in terpintine. Terpinolene also goes by the name delta terpinene.

Terpinolene is not an analgesic or an anti-inflammatory, yet most cannabinoids and terpenoids are one of the two or both.

Terpinolene was concluded to be effective against several species of bacteria. Terpinolene is able to increase total antioxidant capacity levels in white blood cells without changing the total oxidative stress level. Terpinolene is further effective in fighting glial cell cancer and leukemia.


⇩ View A – Z Index of Terpenes ⇩






Terpinolene was elucidated to be toxic against, Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis and Escherichia coli through the disk susceptibility test minimum inhibitory concentrations measurements in a couple studies.


Genotoxic, oxidative and cytotoxic effects of terpinolene were explored with white blood cells. Genotoxicity was evaluated by micronucleus assay, sister chromatid exchanges assay, and 8-oxo-2-deoxyguanosine measurements. Cytotoxicity was detected by lactate dehydrogenase release and MTT assay. All assays were negative. Terpinolene treatment showed statistically significant increases of total antioxidant capacity levels in the cells without changing total oxidative stress levels. This antioxidant effect was also seen in preventing the oxidation of low density lipoprotein, which is helpful in combatting heart disease.


Nasal transmission of terpinolene was concluded to induce sleep in mice. Oral administration may prove more potent.


A key protein involved in progressing cancers, RAC-alpha serine/threonine-protein kinase, was shown to be reduced in leukemia cells with the treatment of terpinolene. Also brain cancer cells were shown to be significantly affected by the terpene as well, and no signs of genetic damage were seen in the normal cells.