Alpha Pinene - Terpene

Alpha Pinene – Terpene

Description:

 

EFFECTS: Anti-bacterial, Anti-cancer, Anti-inflammatory, Bronchodilator, Memory Enhancer.
Strains Containing Alpha-Pinene include: ACDC, Banana Kush, Durban Poison, Granddaddy Purple, OG Kush, and Trainwreck.

At low exposure levels, α-Pinene is a bronchodilator in humans, and is highly bioavailable with 60% human pulmonary uptake with rapid metabolism or redistribution.[12] α-Pinene is an anti-inflammatory via PGE1, and seems to be an antimicrobial. It exhibits activity as an acetylcholinesterase inhibitor, aiding memory. Like borneol, verbenol and pinocarveol (−)-α-pinene is a positive modulator of GABAA receptors. It acts at the benzodiazepine binding site.

 

 


 

Effects

Anti-bacterial – Slows bacterial growth
Anti-cancer- Inhibits cancer cell growth
Anti-inflammatory- Reduces inflammation systemically
Bronchodilator- Opens airway passages
Memory Enhancer- Enhances cholinergic activity

 


Research

Anti-inflammatory

With acute pancreatitis, alpha-pinene treatment reduced histological damage and myeloperoxidase activity in the pancreas and lungs. Furthermore, alpha-pinene pretreatment reduced the production of pancreatic tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6 during acute pancreatitis. In vitro, alpha-pinene inhibited cerulein-induced cell death and cytokine production in isolated cerulein-treated pancreatic acinar cells. This could point to alpha-pinene possibly having beneficial effects with pancreatic cancer and maybe diabetes. It has been shown that alpha pinene has anti-inflammatory effects in human chondrocytes, thus exhibiting potential antiosteoarthritic activity. + alpha pinene was shown to inhibit the interleukin -1beta- induced inflammatory and catabolic pathways, nuclear factor kappa-light-chain-enhancer of activated B cells and c-Jun N-terminal kinases activation, and the expressionof the inflammatory (iNOS) and catabolic (MMP-1 and -13) genes.

Anti-bacterial

As tested through solid medium diffusion procedure, pinene exhibited toxic effects against Staphylococcus aureus, S. epidermidis, Streptococcus pneumoniae and S. pyogene

Anti-cancer

Mice placed in an environment enriched with a-pinene demonstrated reduced melanoma growth, and tumor volume of the mice was about 40% smaller than that in the control mice. In another study, alpha-pinene was identified as an active anti-proliferative compound on liver cancer BEL-7402 cells using the MTT assay. Alpha-pinene inhibited BEL-7402 cells by arresting cell growth in the G2/M phase of the cell cycle, downregulating Cdc25C mRNA and protein expression, and reducing cycle dependence on kinase 1(CDK1) activity.

Memory Enhancer

Alpha pinene has been shown to be a uncompetitive reversible inhibitor of red blood cell acetylcholinesterase in vitro. The essential oil of sage having, camphor, 1,8-cineole, bornyl acetate, alpha pinene and several other terpenes in much smaller concentrations were exposed to human cells. Since many memory-enhancing and dementia drugs are based on inhibiting cholinesterase to enhance cholinergic activity, it is thought that alpha pinene may act as an effective supplement for such conditions.


CBD Oils Containing Alpha Pinene

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